Acyclovir, an antiviral nucleoside analogue, is a widely used agent highly specific for herpes simplex and varicella-zoster viruses. Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.
Is it safe to take acyclovir during pregnancy?
Long-term suppressive therapy can significantly reduce these outbreaks and is likely safe during pregnancy. Acyclovir (Zovirax) and valacyclovir (Valtrex) are the drugs most commonly used for herpes outbreak suppression and treatment during pregnancy. These drugs help reduce how active the virus is.
Can acyclovir harm my baby?
Answer Studies have shown that the use of acyclovir or valacyclovir is not associated with an increase in birth defects. Limited data exist for famciclovir and therefore it would not be considered a first-line choice for treatment of herpes during pregnancy.
Is acyclovir safe in third trimester?
-This drug has been safely used to treat genital herpes in women in all stages of pregnancy. -Women who acquire genital herpes simplex virus (HSV) during late pregnancy should be managed in consultation with maternal-fetal medicine and infectious-disease specialists.
Does acyclovir cross the placenta?
Acyclovir is known to cross the placenta to the fetus. Frenkel et al4 reported the specific pharmacokinetics of acyclovir in pregnant patients with recurrent HSV receiv ing either 200 or 400 mg of acyclovir orally every 8 hours from 38 weeks’ gestation until delivery.
What category is acyclovir for pregnancy?
All formulations of acyclovir are assigned FDA pregnancy category C status ****, which indicates that safety in human pregnancies has not been determined; therefore, the drug should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Are antivirals safe during pregnancy?
Treatment with antiviral medications is recommended for pregnant women or women who are up to 2 weeks postpartum (including following pregnancy loss) with suspected or confirmed influenza and can be taken during any trimester of pregnancy.
What is acyclovir used for in babies?
Acyclovir is used to treat herpes simplex virus (HSV) disease in infants.
Which is better Valtrex or acyclovir?
Acyclovir and valacyclovir are identical drugs that treat herpes simplex viruses. Both drugs treat HSV-1, HSV-2, and herpes zoster viruses. … Valacyclovir, on the other hand, can be taken up to 2 or 3 times daily. Despite their differences in dosing, acyclovir and valacyclovir have little difference in effectiveness.
Is it safe to take acyclovir while breastfeeding?
The American Academy of Pediatrics considers acyclovir to be safe during breastfeeding, according to the researchers. And the current study, the researchers say, confirms that Valtrex is not found in breast milk. They conclude that Valtrex is safe during breastfeeding.
What are contraindications of acyclovir?
The only absolute contraindication to acyclovir is hypersensitivity. Cautions include renal failure/impairment, immunocompromised host, potential risk of thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS)).
What is the mode of action of acyclovir?
Mechanism of Action:
Acyclovir is converted to its triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.